Diuretic and natriuretic responses of lungfish (Protopterus aethiopicus) to arginine vasotocin

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Abstract
Neurohypophysial peptides believed to be natural principles in lungfish were injected into small, unanesthetized Protopterus aethiopicus. Synthetic oxytocin and 8-isoleucine oxytocin had little or no influence on urine flow or composition. Arginine vasotocin, in doses as low as 0.5 [mu]g/kg, increased rates of glomerular filtration, free water excretion, and sodium excretion. There was no evidence for an antidiuretic response to arginine vasotocin comparable to that seen in amphibians.