Angiotensin II stimulates angiotensinogen synthesis in hepatocytes by a pertussis toxin‐sensitive mechanism
- 1 January 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 259 (2) , 301-304
- https://doi.org/10.1016/0014-5793(90)80032-e
Abstract
The role of intracellular messengers in the stimulatory effect of angiotensin II on angiotensinogen synthesis and secretion in hepatocytes was examined. Angiotensinogen secretion was not influenced by modulators of intracellular calcium (calmidazolium, A 23187, Bay K 8644, methoxamine). In contrast, agents decreasing intracellular cAMP (angiotensin II, guanfacine) stimulated, and those increasing cAMP (isoproterenol, glucagon, forskolin) depressed angiotensinogen secretion. An inverse relationship was also observed between cAMP and angiotensinogen mRNA. Pretreatment of hepatocytes with pertussis toxin abolished the stimulation by angiotensin II. It is concluded that angiotensin II‐induced stimulation of angiotensinogen synthesis is initiated by inhibition of adenylate cyclase.Keywords
This publication has 16 references indexed in Scilit:
- Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein GiFEBS Letters, 1989
- Angiotensinogen gene expression in extrahepatic rat tissues: Application of a solution hybridization assayNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1988
- Effect of Various Components of the Renin-Angiotensin-Aldosterone System on Angiotensinogen Production in a Monolayer Culture of Adult Rat HepatocytesHormone and Metabolic Research, 1987
- Induction of Angiotensinogen Synthesis and Secretion by Angiotensin IIClinical and Experimental Hypertension. Part A: Theory and Practice, 1987
- Hormonal and pharmacological alteration of angiotensinogen secretion from rat hepatocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1986
- Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclaseEuropean Journal of Biochemistry, 1985
- Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+Biochemical Journal, 1985
- Chapter 4 Preparation of Isolated Rat Liver CellsPublished by Elsevier ,1976
- Increase of Plasma Renin-Substrate Concentration after Infusion of Angiotensin in the RatClinical Science, 1973
- Stimulation of Angiotensinogen Formation by Renin and AngiotensinExperimental Biology and Medicine, 1973