Cytotoxicity and Cell Cycle Specificity of Homoharringtonine
- 1 August 1977
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 12 (2) , 298-300
- https://doi.org/10.1128/aac.12.2.298
Abstract
The plant alkaloid, homoharringtonine, isolated from Cephalotaxus harringtonia is cytotoxic to HeLa, KB, and L cells growing in monolayer cell cultures. This effect appears to be cell-cycle specific. In synchronized KB cells, protein synthesis was preferentially inhibited in the G(1) and G(2) phases (70 and 45% inhibition, respectively) as might be expected for a protein-synthesis inhibitor.Keywords
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