RADIATION SENSITIVITY OF SPLEEN CELLS IRRADIATED IN VITRO AND IN VIVO

1 January 1968

journal article
Published by American Roentgen Ray Society in American Journal of Roentgenology

Vol. 102 (1) , 46-52
https://doi.org/10.2214/ajr.102.1.46

Abstract

X-irradiation survival response by colony-forming ability was determined for mouse spleen cells. Cells irradiated in vitro or in vivo differed in their radiosensitivity and cells irradiated in vivo were less sensitive than cells irradiated in vitro. The differences appeared to be due to a difference in the slope or D₀ of the survival curve. D₀ in vivo was 109 rad, and in vitro was 91 rad. Oxygen breathing did not alter radioresponse. The extrapolation of cell radioresponse observed in vitro to the in vivo situation may be limited under certain circumstances.

Keywords

SURVIVAL
SPLEEN CELLS
CELLS IRRADIATED
RADIORESPONSE
CURVE
OXYGEN
CIRCUMSTANCES
RADIOSENSITIVITY
BREATHING

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