Quantitative Aspects of Influenza Virus Multiplication

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Abstract
Inoculation of large quantities of influenza virus into the allantoic cavity of embryonated hens' eggs has been shown to result in the production of “incomplete” haemagglutinating virus, which is incapable of further multiplication (1, 2) and which is smaller than the normal infective particle (3, 4). The work reported in this paper was undertaken to find out how many virus particles have to be taken up by a cell to result in the liberation of “incomplete” virus. Theoretical. The provisional hypothesis was adopted that the average yield of virus per cell is not related to the number of infective particles taken up by that cell until a critical number is reached beyond which there is complete suppression of yield. Since the production of “incomplete” virus occurs with large inocula, the critical number of infecting particles which suppresses haemagglutinin production must be greater than the number which suppresses the production of infective virus.

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