Synthesis of [14-14C] daunorubicin and doxorubicin.

Abstract
A new process leading to [14-14C]daunorubicin and [14-14C]doxorubicin with high specific radioactivity is reported. This synthesis is based on the use of 14C-labeled diazomethane for introduction of the label at C-14 in daunomycin and doxorubicin.

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