Interleukin-1-dependent mitogenic responses induced by protoscoleces of Echinococcus multilocularis in mur ine lymphocytes
- 1 March 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Leukocyte Biology
- Vol. 53 (3) , 233-239
- https://doi.org/10.1002/jlb.53.3.233
Abstract
Mitogenic effects of protoscoleces (PSCs) of Echinococcus multilocularis on murine lymphocytes were studied. Spleen cells from normal BALB/c mice showed significant proliferative responses when cocultured with PSCs. Proliferative responses were observed in both the T and B cell populations. The PSCs also stimulated cells of the macrophage/monocyte lineage to secrete inter-leukin-1 (IL-1). Depletion of plastic- and Sephadex G-10-adherent cells from the spleen cell population significant-ly reduced the proliferative responses to PSCs and the low responsiveness was restored by addition of plastic-ad-herent cells to these cultures. Furthermore, addition of anti-lL-l serum to the spleen cell cultures stimulated with PSCs completely suppressed the proliferative responses. These findings demonstrate that the mitogenic effect of PSC on lymphocytes depends on EL-1 secreted by cells of macrophage/monocyte lineage.Keywords
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