Pyruvate Metabolism and Control: Factors Affecting Pyruvic Carboxylase Activity
- 3 July 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3627) , 58-60
- https://doi.org/10.1126/science.145.3627.58
Abstract
Pyruvic carboxylase activated by acetyl coenzyme A is highly active in the mitochondria of rodent liver, and its activity is increased in fasting and alloxan diabetes. In conjunction with acyl carboxylase activated by di- and tricarboxylic acid, it forms a reciprocating control network. Analog models of similar networks tend to correct for perturbations, stabilizing the overall system.Keywords
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