The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide.
- 1 January 1979
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 27 (2) , 492-498
- https://doi.org/10.1248/cpb.27.492
Abstract
The skin of Rana rugosa contained ranatensin-R, a new analogous peptide to ranatensin. Ranatensin-R is heptadecapeptide amide which is a longest analogue of ranatensin ever isolated from the frog skin. Granuliberin-R, dodecapeptide amide, was obtained from the same ranatensin-R fraction during the separation process. The peptide is a new type of amphibian skin peptide which acts on the rat peritoneal mast cell to liberate granules and histamine from the cells.Keywords
This publication has 2 references indexed in Scilit:
- Synthesis of the dodecapeptide amide corresponding to the entire amino acid sequence of granuliberin-R, a new frog skin peptide from Rana rugosa.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978
- A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977