Early Changes of Some Serum Proteins and Metals in Diabetic Children

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Abstract
Serum concentrations of prealbumin, albumin, orosomucoid, magnesium, zinc and calcium were studied in 30 children with newly diagnosed IDDM aged 3-15 years, during the first two years of the disease, and in 44 healthy control children. On admission serum prealbumin was significantly lower in IDDM children (149 .+-. 48 mg/l) (M .+-. SD) han in healthy controls (194 .+-. 39 mg/l) (p < 0.001). During the two years follow-up prealbumin increased significantly, but did not reach the level of healthy controls. Serum albumin was slightly increased at diagnosis (p < 0.01), but later decreased significantly (p < 0.01). Orosomucoid concentrations did not differ between diabetics and controls. Serum magnesium was initially within the reference interval but later decreased, and after 2 years of IDDM it was highly significantly reduced (p < 0.001). Serum zinc was significantly reduced in IDDM children at diagnosis (p < 0.001), but was within the reference interval after one and 2 years. Serum calcium was increased in the IDDM group at diagnosis (p < 0.01), but later normalized. It is concluded that in early IDDM there is a decreased in serum prealbumin and albumin, and serum magnesium decreases progressively, while serum zinc is only transiently reduced.

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