Sequencing and the alignment of structural genes in the nqr operon encoding the Na+‐translocating NADH‐quinone reductase from Vibrio alginolyticus

Abstract
We previously cloned a part of nqr operon encoding the Na+‐translocating NADH‐quinone reductase (NQR) from the marine Vibrio alginolyticus (Hayashi et al., FEBS Lett. 356 (1994) 330–332]. From its nucleotide sequences, four consecutive open reading frames (ORF) encoding the γ‐subunit (27.7 kDa), two unidentified ORFs of 22.6 kDa and 21.5 kDa, and the β‐subunit (45.3 kDa) were recognized. The gene encoding the α‐subunit was located upstream, and together with the recent report by Beattie et al. [FEBS Lett. 356 (1994) 333–338], the nqr operon was found to be constructed from six consecutive structural genes, where nqrl, nqr3 and nqr6 correspond to the α‐, γ‐, and β‐subunits, respectively, of the NQR complex.

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