MODIFICATION OF ADRENALIN INTOXICATION BY ADRENALECTOMY

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Abstract
After single massive, intraperit. doses of adrenalin (0.2 to 0.5 mg. per 100 g. body weight) the majority of normal rats succumbing died acutely within one hr. These showed asphyxia] symptoms from acute pulmonary congestion with hemorrhage and edema. Blood pressure and blood sugar levels remained markedly elevated until death. The survivors recovered rapidly and permanently. Following adrenalectomy, similar doses of adrenalin killed about the same proportion of rats, but in not less than 3 to 24 hrs. This subacute death was characterized by a slow, progressive fall of blood pressure to zero, a decline of blood sugar to a convulsive level, and an absence of pulmonary involvement. The survival time of those that recovered after 24 hrs. was less than that expected in adrenalectomized rats of the strain used. In rats having cortical tissue but no medulla the acute symptoms were more severe than in the normal. Fasting likewise increased the susceptibility of both normal and adrenalectomized rats. Pre-treatment with histamine produced a shift from the acute to the subacute type of death[long dash]a shift similar to that caused by adrenalectomy.

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