Comparison of Concentrations of Amoxicillin and Ampicillin in Serum and Middle Ear Fluid of Children with Chronic Otitis Media

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Abstract
Twenty-eight children aged five to nine years with chronic serous otitis media received a single dose of either ampicillin or amoxicillin by the oral route 1–2 hr before the removal of middle ear fluid by ventilation tubes inserted through the tympanic membrane. At the time middle ear fluid was obtained, a sample of blood was drawn from the patient, and levels of antibiotic in both specimens were microbiologically assayed by a disk diffusion method. Levels of amoxicillin (mean ± standard error [SE], 1.48 ± 1.6 γg/ml) in middle ear fluid were consistently and significantly higher (P < 0.05) than levels of ampicillin (mean ± SE, 6.2 ± 5.0 γg/ml).

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