Synthesis and properties of a series of sterically hindered guanidine bases
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2085-2090
- https://doi.org/10.1039/p19820002085
Abstract
By the reaction of Vilsmeier salts, derived from tetra-alkylureas or from tetra-alkylthioureas, with primary aliphatic amines, a series of sterically hindered penta-alkyl guanidines has been prepared. 2-t-Butyl-1′,1′,3″,3″-tetramethylguanidine and pentaisopropylguanidine combine ease of preparation with a range of resistance to alkylating agents. Preliminary experiments indicate that these inexpensive bases will be useful in organic synthesis.Keywords
This publication has 0 references indexed in Scilit: