Isoniazid in lepromatous leprosy

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Abstract
Isoniazid was given a 6-months trial in eight patients suffering from lepromatous leprosy, some of whom had responded very poorly to previous sulphone treatment. Some form of lepra reaction occurred in all cases, causing treatment to be temporarily interrupted in two instances and dosage to be limited in two others. There was no definite clinical evidence of improvement or deterioration during the trial. There was some evidence, not statistically significant, of bacteriological improvement followed by relapse in half the cases.In the other half there was no change. Sedimentation rates fell in all cases.There were no unequivocal alterations in the results of other laboratory investigations during the course of the trial.The histological reaction is described. It was concluded that isoniazid, used alone under the conditions of this trial, was not an effective treatment for lepromatous leprosy.

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