Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size
- 1 November 1982
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 22 (5) , 923-925
- https://doi.org/10.1128/aac.22.5.923
Abstract
Cefaclor appeared to be an effective antibiotic against both beta-lactamase-positive and beta-lactamase-negative strains of Haemophilus influenzae type b when tested with 10(5) colony-forming units per ml. With inocula in excess of 10(6) colony-forming units per ml, these organisms were neither inhibited nor killed at concentrations of 400 micrograms/ml. This inoculum effect was also demonstrated in time-kill curve studies.Keywords
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