Comorbidity of panic disorder and major depressive disorder: effects on platelet alpha2 adrenergic receptors
- 1 March 1990
- journal article
- research article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 81 (3) , 216-219
- https://doi.org/10.1111/j.1600-0447.1990.tb06483.x
Abstract
Adrenergic receptor dysregulation has been described as occurring in both major depressive disorder (MDD) and panic disorder. Measurements of platelet alpha2 adrenergic receptors in these patients may be confounded by the coexistence or comorbidity of both diagnoses in the same patient. To explore this possibility, we measured platelet alpha2 adrenergic receptors (3H‐clonidine and 3H‐yohimbine binding) in 3 groups of patients (MDD only, panic disorder only, and those showing comorbidity of MDD and panic) and normal controls. Patients with comorbidity of MDD and panic disorder had significantly lower agonist binding (3H‐clonidine).Keywords
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