Viral-Induced Unresponsiveness of Tuberculin-Sensitized Guinea Pig Lymphocytes
- 1 March 1971
- journal article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 136 (3) , 824-829
- https://doi.org/10.3181/00379727-136-35373
Abstract
Blast cell transformation in vitro of lymphocytes obtained from the peripheral blood of guinea pigs after sensitization to mycobacterial antigen was shown to increase after PPD stimulation. However, the cellular activity of lymphocytes was influenced by recent sensitization or immunization of the animals. The blastogenic response of guinea pig lymphocytes to the mitogen PHA was decreased following both the initial tuberculin sensitization and skin testing with PPD. Lymphocytes from tuberculin-sensitized animals demonstrated a fall in responsiveness to in vitro PPD stimulation after the animals were skin tested.Keywords
This publication has 0 references indexed in Scilit: