Natural and Synthetic Polymers as Inhibitors of Drug Efflux Pumps
Open Access
- 26 September 2007
- journal article
- review article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 25 (3) , 500-511
- https://doi.org/10.1007/s11095-007-9347-8
Abstract
Inhibition of efflux pumps is an emerging approach in cancer therapy and drug delivery. Since it has been discovered that polymeric pharmaceutical excipients such as Tweens® or Pluronics® can inhibit efflux pumps, various other polymers have been investigated regarding their potential efflux pump inhibitory activity. Among them are polysaccharides, polyethylene glycols and derivatives, amphiphilic block copolymers, dendrimers and thiolated polymers. In the current review article, natural and synthetic polymers that are capable of inhibiting efflux pumps as well as their application in cancer therapy and drug delivery are discussed.Keywords
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