Newer Aspects in Cellular Radiosensitivity

Publisher Website
Google Scholar
Abstract
Why cells differ in their response to ionizing radiation is a recurrent question among investigators in the field of radiobiology, stressed again in two recent review papers (1, 2). The results herein reported seem to shed light on this query. For a number of years the author's interest has been focused mainly on the unraveling of the factor(s) involved in differential cellular radiosensitivity. This interest evolved from her earliest experiments which demonstrated that when mixed cells of tissues, such as kidneys, tongue, and heart, were exposed in vitro to ionizing radiation (x-rays or radium), the lymphocytes, granulocytes, macrophages, and fibroblasts were gradually destroyed by increased radiation doses, whereas the epithelial cells continued to proliferate (3). Subsequent experiments demonstrated a difference in radiosensitivity between two analogous mammary tumors (4). In the hope of elucidating this phenomenon, experiments were directed toward the detection of intrinsic properties of specific cell...

This publication has 0 references indexed in Scilit: