CHARACTERIZATION OF A NEW INTRA-H-2 RECOMBINANT
Open Access
- 1 September 1974
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 140 (3) , 859-864
- https://doi.org/10.1084/jem.140.3.859
Abstract
This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of glutamic acid and lysine with either tyrosine or pheylalanine (Ir-GLT and Ir-GLphi). The Ir-RE gene was tentatively located in the Ir-1A subregion and the Ir-GLT and Ir-GLphi gene(s) tentatively placed in the Ir-1B subregion. The importance of this recombinant strain to further studies on the fine structure of the I region is discussed.Keywords
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