A hypothesis for the pathogenesis of Crohn's disease based on an ultrastructural study

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Abstract
The epithelioid cells forming the granulomata of Crohn's disease show striking vacuolation from the coalescing of pinocytotic vesicles with double membrane-bound bodies and their subsequent fusion with lysosomal dense bodies. The fine detail of the granulomata in each individual is uniform but varies from case to case in such a way as to suggest an episodic stimulation of pinocytosis and vacuole formation.