ANTIBODIES TO NONHISTONE NUCLEAR ANTIGENS AND ANTILYMPHOCYTE ANTIBODIES AMONG CHILDREN AND ADULTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND THEIR RELATIVES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 11  (5) , 644-647
Abstract
Antibodies to nonhistone nuclear antigens are found with increased frequency in the serum of patients with systemic lupus erythematosus (SLE) and their 1st degree relatives. The prevalence of ANA and antibodies was measured against DNA, RNP [ribonucleoprotein], Sm, SSA and SSB, as well as antilymphocyte antibodies (ALA) in the serum of 24 patients with childhood onset SLE and 94 of their 1st degree relatives, and compared the prevalence of these same antibodies in 8 patients with adult onset SLE and 33 of their 1st degree relatives. Antibodies against DNA, RNP and Sm occurred more frequently in the serum of adult onset SLE patients. Among the 1st degree relatives ALA occurred more frequently in the sera of relatives of patients with childhood onset SLE, and parental antibodies to SSA were associated with the occurrence of childhood onset SLE in 3/24 cases. Since antibodies to SSA were shown to be related to neonatal SLE their possible relationship to childhood SLE requires further study.

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