IMMUNOGENICITY STUDIES OF FOOT AND MOUTH-DISEASE VACCINES AT DIFFERENT CONCENTRATIONS OF ANTIGEN AND SAPONIN

  • 1 January 1980
    • journal article
    • research article
    • Vol. 11  (1) , 35-44
Abstract
Frenkel-type monovalent O1 and C vaccines were tested for immunogenicity under field conditions at a large cattle farm. Vaccines were applied in 4 dilutions to furnish different concentrations of antigen. Each dilution was tested with 4 and 8 mg/dose levels of saponin and without adjuvant. In adult multivaccinated cattle, 1/8 of the standard bovine dose of both preparations developed a satisfactory booster effect and presence or absence of the adjuvant played little role. In the growing (5-7 mo. old) cattle, primary immune response to vaccination depended on the applied dose of antigen; the higher the latter, the greater the immunity that developed. The immunogenicity-enhancing effect of saponin was more pronounced in the young. The result of the immunization was significantly improved by the use of 8 mg saponin/dose compared to that found with 4 mg or no adjuvant in the vaccine. The best vaccination results were obtained with combinations of the highest antigen concentrations with 8 mg saponin/dose. The type O1 antigen proved to be .apprx. half as strong as type C.

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