Immunoglobulin Levels as Related to Age in Nonhuman Primates in Captivity

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Abstract
Immunoglobulin levels in the sera of 60 chimpanzees between 1 and 12 years of age were determined by single radial immunodiffusion using antisera against class-specific determinants of human immunoglobulins showing a reaction of identity between the human and chimpanzee immunoglobulins. Animals older than one year had IgG levels which did not differ much from the values of the young adults. In contrast, the IgM levels remained at about 50% of the young adult values until seven years of age, afterwards gradually rising up to the adult values. The IgA levels, reaching nearly 70% of the adult values already after one year of age of the animals, showed a slow gradual increase. Immunoglobulins of all three major classes showed wide variations in value for all age groups. Immunoglobulin D showed a more homogeneous distribution and its concentration did not change substantially with age.

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