Synthesis of Lysergic Acid Derivatives by Tandem Radical Cyclisation Reactions
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (05) , 357-358
- https://doi.org/10.1055/s-1993-22455
Abstract
A double radical cyclisation of a 2-bromoaniline derivative, initiated with tri-n-butyltin hydride, to construct the lysergic acid ring system is described; formation of a 6-membered D ring is controlled by an intramolecular thermal cyclisation prior to radical addition.Keywords
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