Stimulatory Effect of 5-Azacytidine on 7S Antibody Production in Rats

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Abstract
5-Azacytidine administered to rats simultaneously with immunization by sheep red blood cells resulted in the stimulation of 7S antibody formation while its administration 48 h after immunization causes a marked depression of the synthesis. The response of 7S antibody level to 5-azacytidine depends on the time interval of drug administration while the intensity of the effect is proportional to the dose level of analogue.