Dual Role of Testosterone in Fenvalerate-treated Mice with Respect to Thyroid Function and Lipid Peroxidation
- 1 March 1997
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 17 (2) , 127-131
- https://doi.org/10.1002/(sici)1099-1263(199703)17:2<127::aid-jat418>3.0.co;2-5
Abstract
Effects of testosterone propionate (TP, 2.5 mg kg−1 body weight) in fenvalerate-induced (120 mg kg−1 body weight) thyroid dysfunction and lipid peroxidation were investigated in male mice. Testosterone propionate aggravated in the inhibition of hepatic type I iodothyronine 5′-monodeiodinase (5′D-I) activity, coupled with a decrease in serum triiodothyronine (T3) concentration in pesticide-treated mice. However, it could ameliorate the toxicity as indicated by decreased hepatic lipid peroxidation (LPO) with a marginal but significant increase in superoxide dismutase and catalase activities following fenvalerate treatment. While protective effects of testosterone on LPO indicated its antiperoxidative property, the decrease in 5′D-I activity could be because of the increased accumulation of fenvalerate in the tissues following TP administration. © 1997 by John Wiley & Sons, Ltd.Keywords
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