Inheritance of susceptibility to friend mouse leukemia virus. VIII. Effect of a single genetic locus on the pathogenesis of the leukemia

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Abstract
The effect of the Fv locus on the pathogenesis of Friend virus‐induced leukemia was studied with two pairs of mouse strains which are congenic except for the locus. The rapid spleen enlargement or spleen focus formation which is characteristic of Friend virus infection occurred in the mice with Fvs/Fvs genotype, DDD and C57BL/ 6‐Fvs. These early responses were not seen in the mice with Fvr/Fvr genotype, DDD‐Fvr and C57BL/6. When the infected Fvr/Fvr mice were observed for 150 days, all of the DDD‐Fvr mice, but none of the C57BL/6, developed splenomegaly. Histological studies of the DDD‐Fvr mice revealed erythroblastic, lymphatic or granulocytic leukemia, or myeloproliferative disorder with a prominent megakaryocyte proliferation. This observation indicates that Friend leukemia virus is able to induce various types of leukemias in mice and the early characteristic responses are completely abrogated in the mice with Fvr/Fvr genotype. Involvement of genetic factor (s) other than the Fv locus in the late‐occurring leukemias was suggested.