CARBON TETRACHLORIDE POISONING; A REPORT OF ONE CASE WITH NECROPSY AND ONE NONFATAL CASE WITH CLINICAL LABORATORY STUDIES

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Abstract
Data are presented on 2 cases of CCl4 intoxication, in one of which the termination was fatal. The role of alcohol as an adjuvant to the toxicity of this compound is discussed. In view of the widespread and almost indiscriminate use of this solvent the likelihood of encountering future cases of poisoning is great. The diagnosis is made by determining the extent of both hepatic and renal damage in a patient giving a history of recent or prolonged exposure to this compound. The clinical phenomenon most to be feared is progressive oliguria or anruia. Treatment consists in removal of patient from the site of exposure followed by admn. of specific nutriments for the damaged liver. Adequate fluids should be provided to counteract the loss of those by vomiting and to improve renal elimination. O2 is considered by some investigators to be of benefit and may be used in conjunction with penicillin. Obviously the best and most effective prophylaxis consists simply in never using CCl4 without adequate ventilation.

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