THE AFFINITY OF NARCOTIC AGENTS FOR INTERFACIAL FILMS

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Abstract
The effect of 6 narcotic gases upon the surface tension of lipoprotein-covered water at room temperature (24-25[degree]C) was determined. The film of the water acted as a model for a cellular membrane. It was not determined whether various interactions that took place were due to interactions between lipid film and narcotic or between water and narcotic, facilitated by the presence of lipid. The data does suggest that lipid plays an essential role in membrane activity. It was also found that substances which are not intrinsically surface active can have a profound effect when the composition of the film is suitably chosen.