EFFECT OF FUSARIUM T-2 TOXIN ON HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN THE RABBIT

  • 1 January 1981
    • journal article
    • research article
    • Vol. 45  (4) , 400-405
Abstract
The single i.v. administration of purified T-2 toxin to rabbits at 0.5 mg/kg body wt decreased hematocrit, white blood cell count and serum alkaline phosphatase activity. Plasma clotting time, as measured by the activated partial thromboplastin time assay, was prolonged after i.v. T-2 toxin administration. Administration of T-2 toxin to rabbits at 2.0 mg/kg body wt by gastric intubation produced oral lesions, diarrhea and anorexia, but did not cause significant alteration in hematological and biochemical parameters. The rabbit may be a suitable model for further examination of the biochemical mechanisms involved in the cytotoxic action of T-2 toxin.