Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systemsElectronic supplementary information (ESI) available: full details of laser ablation ICP-MS and QTOF operating conditions, further experimental details for peptide separation and peptide sequencing maps for OmpA. See http://www.rsc.org/suppdata/cc/b1/b108418f/
- 7 December 2001
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 24,p. 2708-2709
- https://doi.org/10.1039/b108418f
Abstract
Proteins from cisplatin treated bacterial cells were partially separated by 1D polyacrylamide gel electrophoresis and analysed by laser ablation inductively coupled plasma mass spectrometry; using peptide fingerprinting methods central to proteomics, the band containing the highest levels of platinum was found to contain outer membrane protein A, which may be involved in cisplatin uptake.Keywords
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