CT1341: INTERACTION WITH SOME ANAESTHETIC AGENTS

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Abstract
The interaction of the steroid anaesthetic agent CT1341 with selected muscle relaxants and volatile agents has been investigated in man. In four patients the effect at the neuromuscular junction was examined. No effect was seen with CT1341 alone and there was no clinically significant interaction with tubocurarine, pancuronium or suxamethonium. A further forty patients in six groups were anaesthetized using CT1341 and either pancuronium or tubocurarine with controlled respiration. One of the volatile agents, halothane, trichloroethylene or methoxyflurane, was then administered and the resulting effect on electrocardiogram, systolic and diastolic blood pressure, pulse rate and nasopharyngeal temperature noted. Three patients given methoxyflurane developed a marked sinus tachycardia which could be evidence of drug interaction. No other effect was observed.

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