Dose-Response Curve for the Blood Pressure Effects of Graded Doses of Histamine

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Abstract
Blood pressure responses of the anesthetized dog to graded doses of histamine were measured and plotted upon rectangular coordinate paper. Result of this plot was a rectangular hyperbola which was fitted to the formula of Brown with slight modification. The final form of the equation was (x + b) (y - a) = k, where k = -ab + c, x = the dose of histamine base in [mu]g/kg, y = the actual fall in blood pressure in mm Hg, and a,b, and c are derived constants. This equation gave a close fit with a low standard error of estimates. The estimate of the biological meaning of the parameters was the same as that proposed by Brown with the exception of the parameter a. In this equation a may be the maximum drug induced fall in blood pressure.