COMPARATIVE EFFECTS OF HYDROCORTISONE, A DERIVED PYRIDO-PYRIMIDINE, AND XEROSIN ON PNEUMONIA PRODUCED IN MICE BY VIRAL AND BACTERIAL TOXIN

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Abstract
Daily parenteral injections of hydrocortisone, a derived pyridopyrimidine (DPP), or the bacterial product, xerosin, suppressed pneumonia produced in mice by Escherichia coli endotoxin. However, only DPP and xerosln suppressed pneumonia induced by the toxicity of Newcastle disease virus (NDV) and delayed the onset of convulsions induced by influenza virus neurotoxin. It is not clear whether the failure of cortisone to affect NDV-induced pneumonia is associated with basic differences between such virus-induced lesions and other inflammatory responses or with the untoward effects of large amounts of hydrocortisone on the host.