Probable role of propionate and butyrate in control of insulin secretion in sheep

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Abstract
A chronic surgical preparation was developed which allowed enrichment of pancreatic arterial blood in experiments performed postoperatively in unanesthetized sheep. Experiments with five adult sheep demonstrated that butyrate stimulated insulin secretion through a direct effect on the pancreas which was not due to associated hyperglycemia or hyperketonemia. Butyrate and propionate at rates of infusion within the physiological range stimulated insulin secretion. Whether propionate affected the pancreas directly was not determined. These results indicate that the liver may indirectly control pancreatic islet function to sheep, because extraction of butyrate and propionate from portal blood by the liver governs the concentrations of these compounds in blood reaching the pancreas.

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