Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis
Open Access
- 3 October 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 325 (14) , 997-1001
- https://doi.org/10.1056/nejm199110033251404
Abstract
Atherosclerosis is characterized by endothelial injury and the proliferation of arterial smooth-muscle cells. The latter may be a result of the release of growth factors from the vessel wall; such growth factors may include an endothelium-derived vasoconstrictor peptide with mitogenic properties. We tested the hypothesis that plasma endothelin concentrations are elevated in persons with symptomatic atherosclerosis, independently of age.Keywords
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