Nitrosamine Studies: Neoplasms of Liver and Genital Mesothelium in Nitrosopyrrolidine-Treated MRC Rats23
- 1 June 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 48 (6) , 1687-1696
- https://doi.org/10.1093/jnci/48.6.1687
Abstract
Nitrosopyrrolidine, a cyclic nitrosamine, produced hepatocellular carcinoma in 25 of 25 MRC rats when fed for 67 weeks at a total dose of 1,340 mg. The histologic features of these tumors are described and related to their intravascular growth behavior and metastafic tendencies. Genital tumors occurred in 7 of 12 male rats, and 4 of these were papillary mesotheliomas of the tunica vaginalis testis, a histologic type rarely described in this species. A review of the literature with respect to the carcinogenic activity of nitroso compounds and their possible relationship to human neoplasia is presented.Keywords
This publication has 0 references indexed in Scilit: