Ferumoxides and Tc‐99m sulfur colloid: Comparison of the tumor‐to‐liver uptake in focal nodular hyperplasia

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Abstract
The tumor‐to‐liver uptake of two reticuloendothelial agents, namely ferumoxides and technetium‐99m (Tc‐99m) sulfur colloid, was compared in focal nodular hyperplasia (FNH). Twelve patients with FNH who had undergone ferumoxides‐enhanced MR imaging and planar Tc‐99m sulfur colloid scintigraphy within 1 year were included from the study. Fourteen patients with FNH with a diameter larger than 3 cm were selected for the comparison. The tumor‐to‐liver ferumoxides uptake was calculated and the Tc‐99m sulfur colloid uptake was assessed visually. Ferumoxides uptake was observed in all but one patient with FNH (mean tumor‐to‐liver ratio = .36). The six tumors showing normal (n = 5) or increased (n = 1) radiocolloid uptake when compared to the liver accumulated more ferumoxides than the eight tumors showing decreased radiocolloid uptake (P < .01). However, in some tumors, no direct relation was observed between ferumoxides and Tc‐99m sulfur colloid uptake. Our observations suggest that ferumoxides uptake might not exactly mimic Tc‐99m sulfur colloid uptake in FNH.