(+)-10α-Hydroxy-4-muurolen-3-one, a New Inhibitor of Leukotriene Biosynthesis from a Favolaschia Species. Comparison with Other Sesquiterpenes
Open Access
- 1 August 1996
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 51 (7-8) , 487-492
- https://doi.org/10.1515/znc-1996-7-806
Abstract
A new inhibitor of leukotriene biosynthesis, (+)-10α-hydroxy-4-muurolen-3-one (1), was isolated from fermentations of Favolaschia sp. 87129. Its structure was established by spectroscopic methods. The compound exhibited no antifungal or antibacterial activities. The effects of 1 on leukotriene biosynthesis were compared with (+)-T-cadinol, (-)-3-oxo-T-cadinol, and (+)-3a-hydroxy-T-cadinol, three related sesquiterpenes.Keywords
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