Inhibition of S-adenosylmethionine decarboxylase from rat liver by synthetic decarboxylated S-adenosylmethionine and its analogs.
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 28 (7) , 2232-2234
- https://doi.org/10.1248/cpb.28.2232
Abstract
Synthetic decarboxylated S-adenosylmethionine and 6 analogs were tested in a decarboxylating system based on rat liver S-adenosylmethionine decarboxylase. All the compounds inhibited the putrescine-activated decarboxylase activity, and were competitive with respect to S-adenosylmethionine. Among the compounds tested, S-5''-deoxyadenosyl-(5'')-2-methylthioethylamine was the most potent inhibitor. The Ki [inhibition constant] value of the inhibitor was 7 times lower than that of decarboxylated S-adenosylmethionine.This publication has 0 references indexed in Scilit: