Mycothiol, 1‐O‐(2′‐[N‐acetyl‐L‐cysteinyl]amido‐2′‐deoxy‐α‐D‐glucopyranosyl)‐D‐myo‐inositol, is the factor of NAD/factor‐dependent formaldehyde dehydrogenase
Open Access
- 9 June 1997
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 409 (2) , 221-222
- https://doi.org/10.1016/s0014-5793(97)00510-3
Abstract
Two different NAD/coenzyme‐dependent formaldehyde dehydrogenases exist, the well‐known NAD/GSH‐dependent (EC 1.2.1.1) and the more recently discovered NAD/Factor‐dependent enzyme. The GSH‐dependent one has been found in eukaryotes and Gram‐negative bacteria, the Factor‐dependent one in two different Gram‐positive bacteria. Previous work also showed that Factor and GSH are not interchangeable in the enzymatic reactions. Here it is revealed that the Factor is identical to mycothiol (MySH), 1‐O‐(2′‐[N‐acetyl‐L‐cysteinyl]amido‐2′‐deoxy‐α‐D‐glucopyranosyl)‐D‐myo‐inositol, a thiol compound which has recently been detected in Actinomycetes. Thus, MySH is GSH's companion as it is the coenzyme for the enzyme which henceforth can be indicated as NAD/MySH‐dependent formaldehyde dehydrogenase.Keywords
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