PHARMACOKINETICS OF CEFOTAXIME IN SHEEP

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (8) , 1488-1491
Abstract
Five healthy adult Merino ewes were each given 2 g of cefotaxime i.v., i.m. and s.c. The serial plasma samples collected after each treatment were analyzed for cefotaxime by a new high-pressure liquid chromatographic method. Plasma concentration time profiles were characterized by a linear 2-compartment model after i.v. administration; the following mean values (.+-. SD) were found: biological half-life, 23 .+-. 8 min; apparent volume of distribution, 5.5 .+-. 1.3 l; plasma clearance, 0.37 .+-. 0.09 l/min; elimination rate constant, 0.066 .+-. 0.014 min-1; rate of diffusion into tissue, 0.013 .+-. 0.013 min-1; and out of tissue, 0.035 .+-. 0.017 min-1. Plasma cefotaxime concentrations in the ewes given the drug i.v., i.m. and s.c. were 113 .+-. 32, 71 .+-. 20 and 38 .+-. 11 .mu.g/ml, respectively, at 15 min; 2.31 .+-. 0.82, 11.3 .+-. 6.6 and 16.4 .+-. 3.7 .mu.g/ml at 120 min; and 1.05 .+-. 1.22, 9.3 .+-. 5.2 and 14.9 .+-. 1.27 .mu.g/ml at 150 min. After cefotaxime was given s.c. and i.m., plasma values were higher for a longer time than they were after the drug was given i.v., probably due to a slower release of drug from the fromer injection sites.

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