Toxicity of Hydroxamic Acid Analogues; Prophylactic and Therapeutic Efficacy Against Nerve Gas Poisoning in Mice.

1 August 1956

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 92 (4) , 660-662
https://doi.org/10.3181/00379727-92-22575

Abstract

A series of analogues of hydroxamic acid were tested for toxicity and for therapeutic efficacy against Sarin in mice. Some showed protection against 1 and 2 LD50''s of Sarin. Toxicity and protective efficacy were not correlative. Effective doses were quite large.

Keywords

CHOLINESTERASE/ANTAGONISTS
HYDROXYLAMINES/EFFECTS
PHOSPHATES/POISONING

This publication has 3 references indexed in Scilit:

ACETYLCHOLINESTERASE .13. REACTIVATION OF ALKYL PHOSPHATE-INHIBITED ENZYME
1952
ACETYLCHOLINESTERASE .11. REVERSIBILITY OF TETRAETHYL PYROPHOSPHATE INHIBITION
1951
A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS
1949