Fluoride Distribution in the Mouth after Fluoride Rinsing

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Abstract
Small volumes of oral fluid (about 1 .mu.l) were sampled from different regions of the mouth to establish the pattern of fluoride distribution and clearance at different sites after rinsing with a solution containing 1,000 ppm F (as NaF). Almost immediately after rinsing, the concentrations of fluoride varied considerably from place to place in the mouth. This was due to variations in the rate of fluoride clearance, which seemed to depend largely upon the anatomical disposition of salivary ducts, the rate of salivary secretion and perhaps upon other individual variations related to dental occlusion and the anatomy of the oral cavity. In most other subjects examined, clearance was more rapid in the lower, mandibular part of the mouth than e.g. in the central region of the upper labial vestibule. Differences in the rate of fluoride clearance were often much greater from one individual to another than were the differences in one individual measured on different days.