EFFECTS OF COMPOUND 48/80, CHLORPROMAZINE, DEXTRAN, AND RESERPINE IN RABBITS FED A 1% CHOLESTEROL DIET

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Abstract
The effects of drugs such as compound 48/80, chlorpromazine, dextran, and reserpine which influence the release and metabolism of biogenic amines, have been studied in rabbits fed a 1% cholesterol diet for 5 and 9 weeks. It was found that chlorpromazine, dextran, reserpine, and reserpine + compound 48/80 decreased the serum total cholesterol and lipid levels during the first 3 weeks of the 9-week experiment. This hypolipemic effect was no longer evident in the latter part of the experiment. Chlorpromazine and dextran reduced the serum total cholesterol, total lipid, and total protein levels after the 4th week of the 5-week experiment. The aortic fatty deposits of the treated groups were less abundant after 5 weeks of experiment but not significantly so after 9 weeks. Compound 48/80 had no decreasing effect on serum lipemia or aortic deposits in either experiment. The effects obtained with dextran and reserpine were not due to variations in exogenous cholesterol intake or intestinal absorption of the ingested cholesterol. However a smaller intake of exogenous cholesterol may partly account for the effects observed with chlorpromazine, and a reduced intestinal absorption for the effects observed with reserpine + compound 48/80.