Enhancement of Diazepam and γ‐Aminobutyric Acid Binding by (+) Etomidate and Pentobarbital
- 1 February 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 41 (2) , 578-585
- https://doi.org/10.1111/j.1471-4159.1983.tb04778.x
Abstract
(+) Etomidate and pentobarbital enhance [3H]diazepam and [3H]γ-aminobutyric acid ([3H]GABA) binding to cerebral cortex membranes. Both (+)etomidate and pentobarbital increase the affinity of [3H]diazepam for its binding sites. In contrast, they increase the Bmax of both the high- and low-affinity GABA receptor sites. The enhancement of [3H]diazepam and [3H]GABA by (+)etomidate and pentobarbital is blocked by GABA antagonists. These results indicate that hypnotic drugs such as (+)etomidate and pentobarbital, which are not structurally related, modulate diazepam and GABA binding sites via similar mechanisms.Keywords
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