Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/c 17,20 -lyase and 5α-reductase
- 1 October 1998
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 6 (10) , 1683-1693
- https://doi.org/10.1016/s0968-0896(98)00110-2
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Synthesis and Evaluation of Pregnane Derivatives as Inhibitors of Human Testicular 17α-Hydroxylase/C17,20-Lyase,Journal of Medicinal Chemistry, 1996
- Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic CancerJournal of Medicinal Chemistry, 1995
- Inhibition of androgen synthesis by 22-hydroximino-23,24-bisnor-4-cholen-3-oneThe Prostate, 1995
- Pharmacology of novel steroidal inhibitors of cytochrome P45017 (17α-hydroxylase/C17–20 lyase)The Journal of Steroid Biochemistry and Molecular Biology, 1994
- 4-pregnene-3-one-20β-carboxaldehyde: A potent inhibitor of 17α-hydroxylase/C17,20-lyase and of 5α-reductaseThe Journal of Steroid Biochemistry and Molecular Biology, 1992
- Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acidJournal of Medicinal Chemistry, 1990
- Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesisJournal of Medicinal Chemistry, 1990
- 17β-(Cyclopropylamino)-androst-5-en-3β-ol, a selective mechanism-based inhibitor of cytochrome P45017α (steroid 17α-hydroxylase/C17–20 lyase)Biochemical and Biophysical Research Communications, 1989
- Inhibitory effect and interaction of stanozolol with pig testicular cytochrome P-450 (17.ALPHA.-hydroxylase/C17.20-lyase).CHEMICAL & PHARMACEUTICAL BULLETIN, 1989
- Inhibition of testicular 17α-hydroxylase and 17,20-lyase but not 3β-hydroxysteroid dehydrogenase-isomerase or 17β-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugsThe Journal of Steroid Biochemistry and Molecular Biology, 1987