Effects of vinblastine on catecholamine‐biosynthetic enzymes in heart, sympathetic ganglion and adrenal glands of rats

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Abstract
1 The effect of vinblastine on the activities of dopamine-β-hydroxylase (DBH) in heart, superior cervical ganglion and adrenal glands of rats and tyrosine hydroxylase (TH) and phenylethanolamine-N-methyl transferase (PNMT) in adrenal glands was examined. 2 In the superior cervical ganglion and heart, DBH activity decreased within hours, reached a minimum in 3 to 5 days and slowly returned towards normal over the next 2 weeks. 3 There was an increase in the activities of TH, DBH and PNMT in adrenal glands which was prevented by adrenal denervation. 4 When the same total dose of vinblastine was administered subdivided over a period of 5 days, enzyme activities in heart, superior cervical ganglion or adrenal glands remained unchanged.